Interference of natural mouse hepatitis virus infection with cytokine production and susceptibility to Trypanosoma cruzi
Identifieur interne : 001166 ( Main/Exploration ); précédent : 001165; suivant : 001167Interference of natural mouse hepatitis virus infection with cytokine production and susceptibility to Trypanosoma cruzi
Auteurs : A C T. Torrecilhas ; E. Faquim-Mauro ; A V Da Silva ; I A AbrahamsohnSource :
- Immunology [ 0019-2805 ] ; 1999.
Abstract
Mouse hepatitis virus (MHV) infection can have a pronounced impact on several investigation areas. Reports on natural MHV outbreaks are rare and most studies have been conducted by deliberately infecting mice with MHV laboratory strains that cause moderate to severe disturbances to the immune system. We have investigated the effects of a natural acute outbreak of MHV in our otherwise specific-pathogen-free (SPF) inbred mouse colonies, and of enzootic chronic MHV infection on cytokine production and resistance to the intracellular pathogen
Url:
DOI: 10.1046/j.1365-2567.1999.00719.x
PubMed: 10233719
PubMed Central: 2326758
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Mouse hepatitis virus (MHV) infection can have a pronounced impact on several investigation areas. Reports on natural MHV outbreaks are rare and most studies have been conducted by deliberately infecting mice with MHV laboratory strains that cause moderate to severe disturbances to the immune system. We have investigated the effects of a natural acute outbreak of MHV in our otherwise specific-pathogen-free (SPF) inbred mouse colonies, and of enzootic chronic MHV infection on cytokine production and resistance to the intracellular pathogen <italic>Trypanosoma cruzi</italic>
. We found that BALB/c and/or C57BL/6 SPF mice that had been injected with <italic>T. cruzi</italic>
blood trypomastigotes from recently MHV-contaminated (MHV<sup>+</sup>
) mice developed significantly higher parasite blood counts, accelerated death, and showed higher IL-10 production by spleen cells than their counterparts whose <italic>T. cruzi</italic>
inoculum was derived from MHV-negative (MHV<sup>−</sup>
) donors. Interferon-γ (IFN-γ) production by MHV<sup>+</sup>
and MHV<sup>−</sup>
mice was not significantly different. In contrast, <italic>T. cruzi</italic>
infection of chronically MHV-infected mice did not result in major changes in the course of infection when compared with that observed in mice from MHV<sup>−</sup>
colonies, although a trend to higher parasitaemia levels was observed in BALB/c MHV<sup>+</sup>
mice. Nevertheless, both BALB/c and C57BL/6 <italic>T. cruzi</italic>
-infected MHV<sup>+</sup>
mice had diminished IFN-γ production to parasite-antigen stimulation in comparison with similarly infected MHV<sup>−</sup>
mice. Interleukin-10 (IL-10) production levels by spleen cells did not differ between chronic MHV<sup>+</sup>
and MHV<sup>−</sup>
mice, but IFN-γ neutralization by monoclonal antibody treatment of anti-CD3-stimulated spleen cell cultures showed higher levels of IL-10 synthesis in MHV<sup>+</sup>
BALB/c mice.</p>
</div>
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<name sortKey="Faquim Mauro, E" sort="Faquim Mauro, E" uniqKey="Faquim Mauro E" first="E" last="Faquim-Mauro">E. Faquim-Mauro</name>
<name sortKey="Torrecilhas, A C T" sort="Torrecilhas, A C T" uniqKey="Torrecilhas A" first="A C T" last="Torrecilhas">A C T. Torrecilhas</name>
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